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Tissue Plasminogen Activator 정의: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
recombinant tissue plasminogen activator 정의: A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, recombinant tPA increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42033&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42033&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C39607" NCI Thesaurus)
Alteplase 정의: A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, recombinant tPA increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. (NCI05)
Tissue Plasminogen Activator 정의: Tissue Plasminogen Activator isoforms 1 (562-aa, 63-kD), 2 (291-aa, frameshifted with distinct C-terminus), and 3 (516-aa, deleted Ex4) are encoded by human PLAT Gene (Peptidase S1 Family). EGF-like, fibronectin I, and kringle domains mediate fibrin, LRP1, annexin II, and cytokeratin 8 binding. TPA also binds to laminin, fibronectin, and mannose receptor. Inhibited by PAI-1, serine protease TPA is widely expressed as an active single chain, then secreted, and cleaved by plasmin, tissue kallikrein, or factor XA to a fully active disulfide linked A/B-protein; N-heavy chain and C-light chain. Important in cell migration and tissue remodeling, TPA activates (increased by fibrin or heparin) plasminogen to fibrinolytic plasmin conversion by hydrolyzing a specific Arg-Val bond. Altered activity causes hyper- or hypofibrinolysis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
Tissue Plasminogen Activator 정의: Tissue plasminogen activator (PLAT) is a serine protease that activates the proenzyme plasminogen to plasmin, which in turn is responsible for fibrinolytic activity. PLAT is synthesized in vascular endothelial cells as a single polypeptide chain. Proteolytic cleavage of the single chain protein at a centrally located arginine-isoleucine bond by plasmin gives rise to a 2-chain disulfide-linked form, composed of the N-terminally derived heavy chain and the C-terminal light chain.
Tissue Plasminogen Activator 정의: A secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. (from LocusLink)
 
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